Saturday, May 19, 2018

IMPORTANCE OF--- VITAMIN K2 !!!


VITAMIN  K2


The little-known vitamin with big benefits


Are you concerned about osteoporosis, heart disease, cancer, or diabetes? Are you taking calcium or vitamin D? Have you heard conflicting reports about the safety of calcium supplements? If you answered yes to any of these questions, this booklet is for you. From bone loss and arterial plaque to premature aging and varicose veins, vitamin K2 may be a missing piece to the puzzle of many common ailments.
This handy little booklet explains:

What vitamin K2 is, and the essential difference between Kj and K2

Why deficiencies of this important nutrient have become widespread

The many health benefits of vitamin K2

What foods contain vitamin K2 - or used to!

How to pick an effective vitamin K2 supplement

Why vitamin K2 is critical if you're taking calcium


IVITAMIN K2
Keeping Calcium in its Place
Understanding the importance of vitamin K2
Kate Rheaume-Bleue, ND
INTRODUCTION

Are you concerned about bone health, heart health, cancer, or diabetes? Have you been taking calcium or vitamin D? Have you heard conflicting news reports about the safety of calcium supplements? If you answered yes to any of these questions, this booklet is for you. It will introduce you to vitamin K2, a little-known vitamin with big health benefits.

A new vitamin?

It's not every day you hear of a new vitamin. In fact, it has been decades since anyone "discovered" or identified a novel nutrient with health benefits as profound as vitamin K2. With so much health information (and dis-information) available today, it's easy to become overwhelmed or skeptical when it comes to the latest, greatest super-nutrient.

But vitamin K2 is different. This nutrient was once abundant in our diets, protecting us from heart attack, stroke, brittle bones, cancer, and a myriad of other now-all-too-common ailments.

Vitamin K2 is a nutrient that offers significant health benefits and yet was overlooked for almost 70 years due to a case of mistaken identity. It provides a missing piece to the nutritional puzzle of ailments such as osteoporosis, heart disease, cancer, varicose veins, diabetes, arthritis, and others. In the following pages you will learn what vitamin K2 is, what it does in the body, how it has all but vanished from our diets, and how we can get it back, as well as how much you need for optimal health, and what to look for in a vitamin K2 supplement.

My book Vitamin K2 and the Calcium Paradox: How a Little-Known Vitamin Could Save Your Life (Wiley & Sons, 2012) provides comprehensive coverage of every thing you need to know about vitamin K2, including the broad range of benefits possible with vitamin K2 and a complete list of scientific references supporting the data. You will find some of those references at the back of this booklet.
Kate Rheaume-Bleue, ND March 2013

THE CALCIUM CONUNDRUM

For years nutritionists, dieticians, and medical professionals alike have emphasized dietary calcium intake and calcium supplements (along with vitamin D) as the key to strong bones.

Several recent studies have shown that people who take calcium supplements experience significantly more heart attacks and strokes than those who don't. It turns out that a portion of the calcium not taken up by bones ends up lining the arteries, leading to hardening of the arteries, or atherosclerosis (heart disease). However, simply giving up calcium supplements may be shortsighted, since heart disease is the leading killer of both men and women whether or not they take calcium supplements. In other words, calcium can get into the wrong places and cause harm in anyone... but it's not calcium's fault! And calcium is an essential nutrient for healthy teeth and bones.

Looking only at calcium intake, we would never understand why calcium is misdirected from the bones and ends up in the arteries instead. How can we get calcium to go where it's needed? What keeps calcium in its place?
We are not powerless in the face of this calcium conundrum. The body has ways of dealing with this mineral and keeping it where it belongs. North Americans didn't always suffer from heart disease and hip fractures to the extent that we do today. Some developed countries don't have anywhere near the rates of heart attack, stroke or osteoporosis that we have in North America. How is it that the citizens of countries like France and Japan have escaped this calcium conundrum?

As you will see, the diets in those countries, and others, provide high levels of the one nutrient that tells calcium where to go: vitamin K2.

WHAT IS VITAMIN K2?

Vitamin K2 (menaquinone) is a fat-soluble nutrient that works with vitamin D to guide calcium into bones and teeth and, more importantly, helps keep calcium out of soft tissues like arteries. It also activates special proteins that have powerful cancer-fighting abilities. If you take vitamin D you may see even greater benefits when you supplement with vitamin K2.
How much vitamin K2 are we getting in our daily diet? The short answer is "not enough". Research in 2007 showed that most apparently healthy adults do not have enough dietary vitamin K2 to fully meet their body's requirement for this nutrient. When there isn't enough vitamin K2 to keep calcium in its place all the time, it opens the door to increased risk for heart disease, osteoporosis, cancer, and a number of other serious health conditions. Alternately, having adequate vitamin K2 intake protects us against all of those health problems and more. But more on that later. Let's take a look at why vitamin K2 was overlooked for so long.

Vitamin K1 versus K2

If you are wondering why you haven't heard about vitamin K2 until now, it's because it was overlooked for decades and is still often misunderstood. Another form of vitamin K, vitamin K1 (phylloquinone), stole the spotlight. The body uses vitamin K1 for blood clotting and it is easily obtained in our diets by eating green leafy vegetables. Vitamin K1 is so important for coagulation that the body has a special mechanism to reuse vitamin K1. That means if you only eat green leafy vegetables once in a blue moon, the body can always find and recycle enough K: to ensure proper blood clotting. A deficiency of vitamin K1 is extremely rare. When it does occur, usually as a result of liver disease or some other serious illness, the symptoms of K1 insufficiency are obvious: bruising and bleeding. The vitamin K1 recycling mechanism is so efficient that you can afford to take this nutrient for granted; we don't have to worry about our intake of K1, and there is no need for supplementation. This is not the case with vitamin K2.

Vitamins K1 and K2 were both discovered in the 1930s and at the time researchers assumed they were both blood-clotting vitamins. That assumption caused vitamin K2 to be ignored for more than two generations.

We eventually learned that vitamin K2 does not come from green leafy vegetables, does not participate in blood clotting and it is not recycled in the body. Studies show that without vitamin K2 in our diets on a daily basis, we can become deficient in this nutrient in as little as one week. Furthermore, the symptoms of vitamin K2 deficiency are not obvious because they are, for the most part, internal. A lack of vitamin K2, even a marginal deficiency, can permit osteoporosis, heart disease, diabetes, and cancer to quietly creep up on us.

It was long presumed that vitamin K1 was the more important of these sibling nutrients, since vitamin K1 is present in much higher amounts in our diet. In fact, although vitamin K1 is more abundant in foods, we only absorb 5-10% of what we ingest. On the other hand, while vitamin K2 is less plentiful in the diet, we absorb almost 100% of what we consume. That makes the dietary contribution from vitamins K1 and K2 about equal. The difference is that we have a back up mechanism to prevent
vitamin K1 deficiency that doesn't exist for vitamin K2, so we need to be more mindful of our vitamin K2 intake.

When we consume the pro-coagulant vitamin K1 from vegetables it is transported from the intestines to the liver, where it aids the body's coagulation mechanisms. Calcium-controlling vitamin K2 from foods is also transported to the liver after absorption, but is not destined to stay there. Instead, it is packaged up and sent back out into circulation so it can reach the heart, brain, bones, and other tissues where it facilitates healing. Below is a chart that compares these two nutrients at a glance. 

Understanding the difference between them will help you ensure you are getting the right kind of vitamin K in your diet and supplements.
Vitamin K,1 vs. vitamin K2


K, (phylloquinone)
K2 (menaquinone)
Physiological action
Blood clotting
Appropriate calcification
Food sources
Green leafy vegetables
Natto (fermented soybeans), goose liver, certain cheeses, egg yolks and dairy product from grass-fed animals
Can be recycled by the body
Yes (so dietary requirements are minimal)
No (so dietary intake is crucial)
Deficiency
Very rare, leads to bleeding
Common - manifests as osteoporosis, heart disease, cancer, varicose veins, etc.
Ability to build bone and fight heart disease
Slight
Significant
'Adapted from: Rheaume-BIeue, K. Vitamin K2 and the Calcium Paradox: How a Little-Known Vitamin Could Save Your Life. Wiley & Sons, 2012.



MAJOR HEALTH BENEFITS OF 
VITAMIN K2
Now you know that vitamin K2 doesn't participate in coagulation. Instead, it ushers calcium into the right places and out of the wrong places. This makes it especially helpful for bone health, heart health and, surprisingly, cancer prevention. We'll examine each of these major benefits individually.

Bone health

While your skeleton seems solid and unchanging, bones are in fact constantly being broken down and rebuilt (a process called remodeling) to maintain strong, healthy bone tissue. If, over time, the breaking down process exceeds the rate of rebuilding, bones lose their density, becoming
more porous, brittle and prone to breaking, a condition known as osteoporosis. Up to 50% of women and 30% of men experience fractures due to osteoporosis. You may not realize it, but this is a significant cause of death, since many people die due to complications following a fracture. Many of those who survive bone fractures never again live or walk independently. Osteoporosis prevention is therefore extremely important.
For years the standard non-prescription recommendation for osteoporosis prevention and treatment began and ended with calcium and vitamin D. Calcium and vitamin D absolutely help increase bone density, but not always as much as we'd like. The recommended dose of calcium has gradually increased to 1200,1500 and even 2000 mg daily. These huge doses of calcium are based on the idea that, if a little is good then more is better. Based on that logic, if we just took enough calcium it would cure osteoporosis. But it doesn't work that way. Merely taking calcium, with or without vitamin D, provides no guarantee that the mineral is getting into our bones and staying there. Keeping calcium in our bones is the job of vitamin K2.


Vitamin K2 boosts bone health in a number of ways. Very simply, it activates a protein called osteocalcin that takes dietary calcium and guides it into bones and teeth to improve bone mineral density (BMD).

Studies show vitamins K2 and D3 together increase BMD far better than either nutrient alone. But the bone benefits of vitamin K2 go beyond its effect on bone density. BMD is only one aspect of bone health, although it's the one that gets the most attention. Vitamin K2's ability to improve bone quality and strength, and reduce fracture risk, is significantly greater than its impact on BMD.

Osteoporosis becomes a greater concern for women after menopause. The natural decline of estrogen can negatively impact bone strength in multiple ways. Vitamin K2 has been shown to fight osteoporosis by counteracting these changes in bone health. In areas where vitamin K2 consumption is high (in certain regions of Japan, for example) osteoporosis is uncommon and women experience far fewer bone fractures. In other words, osteoporosis is not inevitable.

For women, increasing vitamin K2 intake and/or taking a vitamin K2 supplement is extremely important as menopause approaches, to help prevent the onset of bone loss. That being said, many women only learn about vitamin K2 later in life, when osteopenia (mild or pre-osteoporosis) or even more severe bone loss has already set in. Even then, it's not too late to benefit from vitamin K2.

How quickly improved bone health occurs after increasing vitamin K2 intake varies from person to person. The most recent clinical trials show that the maximum benefits for bone and heart health are seen within 2-3 years. That may sound like a long time, but keep in mind that osteoporosis and heart disease don't develop overnight. It took decades of K2 deficiency for calcium to leech out of bones and build up in arteries. A significant improvement within 2-3 years is worth waiting for.

Heart health

For years the major focus of cardiovascular disease prevention and treatment has revolved around cholesterol. People are encouraged to eat foods with no or low cholesterol, to have their cholesterol levels tested, and to take medications to reduce it, if necessary. Given this cholesterol fixation, it might surprise you to learn that 50% of people who have heart attacks have normal cholesterol levels. How can that be?

It turns out that whether cholesterol is high, low, or normal, what actually clogs arteries is calcium-laden arterial plaque.

Calcium has the potential to accumulate on the inner walls of arteries in a process called atherosclerosis or "hardening of the arteries". This can eventually cause a blockage in one or more of the arteries that provide blood to the heart, resulting in a heart attack. If the blockage happens in the brain, the result is a stroke. The amount of calcium found in arteries is directly proportional to the amount of arterial blockage - and to the risk of suffering a heart attack. While recent studies point the finger at calcium supplements as a factor in heart attack and stroke, the fact is that heart disease is the number one cause of death for people who don't take calcium supplements too. That means we all need to do what we can to keep calcium out of our arteries, and abandoning calcium supplements provides no assurance of clear arteries.

Cleaning up arterial calcium

The body has a number of safeguards to prevent and reverse hardening of the arteries. Of these mechanisms, scientists agree that one is particularly important and powerful. It involves a vitamin-K2-dependent protein called MGP (matrix gla protein). MGP is produced in soft tissues, such as
blood vessels, but it remains inactive until vitamin K2 arrives to switch it on. Once activated by vitamin K2, MGP will scour blood vessels of calcium deposits.

Vitamin-K2-activated MGP removes calcium from areas where calcium is not supposed to be, such as arteries, veins, and other soft tissues. 
Reversing heart disease may sound incredible, but the body has always had the means to prevent and reverse the build up of arterial plaque; it just needs certain nutrients (notably vitamin K2) to do it. The scarcity of vitamin K2 in our modern diets is one of the reasons heart disease - which used to be rare and is still much less common in some countries - has become the leading killer of men and women in North America.

Vitamin K2 has been shown to reduce arterial calcification and improve blood vessel flexibility. This effect is seen not just in the coronary arteries that feed the heart itself, but also in the aorta, the heart valves, and just about every other blood vessel in the body.

Cancer protection

Vitamin K2 activates a third protein, "growth arrest sequence-6 protein" or Gas6, which regulates cell growth. This makes K2 a powerful ally in preventing and defeating cancer. Studies show K2 encourages cancer cells to die or differentiate into normal, healthy, non-cancerous cell types. For this reason K2 has important anti-cancer effects throughout the body.
The European Prospective Investigation into Cancer (EPIC) study followed 24,000 men and women over ten years to determine risk factors for cancer. It found that people with the highest intake of vitamin K2 had a 30% lower rate of cancer, and death from cancer, than people with low K2 intakes. This was especially true for lung and prostate cancer, the two biggest cancer killers of men. The study found that the greatest dietary source of vitamin K2 in the European diet was cheese, and that cheese consumption had a significant impact on cancer prevention.

Multiple studies demonstrate the importance of K2 for different kinds of cancer. Vitamin K2 has been shown to delay the onset of liver cancer in people with hepatitis and has a positive impact on leukemia. Further studies show K2 combats cancer in the colon, stomach, brain, breast, nose, throat, and mouth.
OTHER BENEFITS OF VITAMIN K2
Anti-aging

The most important new theory of aging is called the triage theory. It suggests that when dietary availability of a vitamin or mineral is moderately inadequate, nature will ensure that essential short-term survival body functions are protected, at the expense of long-term needs, such as prevention of aging. In other words, if we are even slightly lacking in nutrient intake we might not notice it today, but we'll pay for it in the future in terms of having more age-related complaints. An optimal daily intake of dietary nutrients, therefore, is one that meets our needs not just for today but for a lifetime.

While the triage theory does not imply that any one vitamin or mineral deficiency is the cause of age-related disease, the theory's authors did test their theory by examining vitamin K. Simply put, short-term inadequacy of K vitamins has been shown to have long-term health consequences. Since we know that vitamin Kj deficiency is rare due to recycling, that leaves adequate vitamin K2 intake as the critical factor in preventing such ravages of time as osteoporosis, heart disease, cancer, and even wrinkles.

Brain and neurological health

The brain contains one of the highest concentrations of vitamin K2 in the body and this nutrient plays several important roles in the health of the brain and nervous system. For example, vitamin K2 has been shown to prevent brain damage associated with lack of oxygen. If brain cells are deprived of oxygen for any reason, they can be permanently damaged. This can happen in conditions such as strokes and TIAs (transient ischemic attacks or recurrent "mini-strokes"). If oxygen supply to the brain is interrupted during birth, this can lead to cerebral palsy, with lifelong consequences. Fat-soluble-vitamin research states that taking vitamin K2 during pregnancy could prevent cerebral palsy. Similarly, vitamin K2 can potentially buffer the damage done to brain cells due to lack of oxygen during a stroke or TIA.

Vitamin K2 also interferes with the formation of free radicals in the brain, helping to prevent or delay the onset of Alzheimer's disease and other forms of dementia, and age-related brain degeneration.

Dental and oral health

Just under your tooth's enamel (the outermost and visible layer) lies a layer of tissue called dentin. Unlike enamel, dentin has the potential to continue to form throughout life. Dentin also produces MGP, which plays a critical role in maintaining dental health. In fact, although the body doesn't really store much vitamin K2, it does concentrate vitamin K2 in the saliva glands, so this important nutrient is delivered directly to the teeth and gums. When vitamin K2 is abundant, it helps teeth resist the action of bacteria that might otherwise eat holes through the enamel and into the dentin. Vitamin K2 complements good cavity-fighting oral hygiene. Anecdotally, many people who take vitamin K2 supplements report a lessening of dental plaque and tartar and improved gum health.

Diabetes

Osteocalcin, the vitamin-K2-dependent bone-building protein, has been shown to influence insulin sensitivity.

Insulin is a hormone that allows dietary sugar from our blood stream to enter the body's cells to provide energy. Adult onset or type 2 diabetes exists when the pancreas produces insulin but the body's cells don't respond to it efficiently. Consequently sugar continues to circulate in the blood stream longer than it should, which can lead to many serious health problems.

Vitamin K2 deficiency may be a key reason why people with diabetes are prone to osteoporosis, heart disease, and kidney disease. In clinical trials vitamin K2 supplementation has been shown to improve insulin resistance, helping the body's cells to fight diabetes.

Wrinkles

Calcium can accumulate microscopically on the elastic tissues in the skin. When this happens, skin becomes less elastic and sags. Vitamin K2 fights skin aging and the development of wrinkles by protecting the elasticity of skin in the same way it safeguards the elasticity of arteries and veins. No need to apply it topically though, the same K2 you take to protect your bones and heart will work its magic on your skin from the inside.

Varicose veins


Vitamin K2 plays an important role in preventing and healing varicose veins. Calcium can accumulate in the walls of veins in a similar fashion to the way it accumulates in arteries. This can slow blood flow, causing the veins to bulge out, eventually becoming distended, hard, and prominently visible through the skin. MGP, the same vitamin-K2-dependent protein that protects arteries, is involved here. While family history predisposes us to varicose veins, vitamin K2 intake is a controllable factor that can help minimize unsightly vein appearance and discomfort.

Muscle cramps

Although generally associated with sports injuries, muscle cramping also affects non-athletes. Muscle cramps are common in adults and become increasingly frequent with age. Thirty percent of people over the age of 60, and 50% of people over the age of 80, suffer with occasional or frequent leg muscle spasms. Leg cramps (sometimes called a "charley horse") can last from a few seconds to several hours and may wake sufferers at night.

Vitamin K2 (in the form of MK-7) has been shown to decrease the frequency and severity of leg cramps. Leg cramps gradually return if vitamin K2 is discontinued. Magnesium supplementation is also helpful for muscle cramps.

Fertility

Osteocalcin, the same vitamin-K2-dependent protein that builds bones and teeth, has a significant influence on sperm production. Osteocalcin binds to cells in the testicles that produce testosterone and boost sperm count. Couples planning a family or trying to conceive should ensure both partners are getting optimal amounts of vitamin K2.

Facial development

During pregnancy vitamin K2 has a major impact on the healthy development of the facial structures of the fetus. Adequate vitamin K2 intake helps ensure a wide, healthy facial structure with lots of room for the adult teeth to eventually grow into place. A vitamin K2 deficiency during pregnancy, on the other hand, causes development of a narrower jaw that can lead to crowded teeth or the need for orthodontics (braces).


WHO BENEFITS FROM 
VITAMIN K2?

As you have no doubt realized, the many health benefits of vitamin K2 make this an essential nutrient for a healthy life. Specifically, vitamin K2 is as important as folic acid is for pregnant women. In the first trimester the nutrient is critical for the development of primary teeth and healthy facial structure; in the second trimester the formation of adult teeth and the skeleton requires K2. Despite the importance of K2 in early pregnancy, studies show that K2 levels tend to be at their lowest in the third trimester, so expectant mothers should continue to pay attention to their K2 intake at that time. Experts conclude that adequate K2 intake during pregnancy may prevent cerebral palsy caused by birth trauma.

Vitamin K2 intake continues to be crucial during childhood and adolescence, since the rate of bone growth and turnover is highest at that time. Children and teens have especially high requirements for vitamin K2 to nourish their growing bodies and ensure healthy teeth and bones.
Vitamin K2 has also been shown to counteract the negative changes in bone density experienced by menopausal women. Both men and women over 50 show serious vitamin K2 deficiencies, accelerating the rate of bone loss and vascular calcification.


Vitamin K2 from supplements


Since meat and dairy from grass-fed animals are not readily available, natto can be hard to love, and cheese is a challenge when watching your weight, vitamin K2 supplements may be the best, most consistent, convenient source of life-saving vitamin K2. There are two different types of K2 supplements on store shelves. Understanding the big difference between them is key to getting the results you seek.

Menaquinone-7 (MK-7) supplements As mentioned above, MK-7 is a form of vitamin K2 derived from the Japanese fermented soybean food called natto. This form of vitamin K2 offers several advantages over other forms. MK-7 has a long half-life in the body, meaning it circulates in the blood for a day or two, which means that a convenient, single daily dose will meet your menaquinone needs. Because this form of vitamin K2 stays in the blood longer, MK-7 can be effective in relatively small amounts. About 200 meg of MK-7 per day is required to meet the body's need for K2 and to activate all K2-dependent proteins. The majority of clinical trials on adults were conducted using approximately 200 meg of MK-7, although people who eat natto daily get at least twice that amount from their diet.

For anyone concerned about the potentially harmful effects of some soy products, fermented soy poses no such problems, and vitamin K2 supplements from soy do not contain any harmful soy compounds. Unless someone has a true anaphylactic allergy to soy, which is rare, MK-7 is the best choice among the vitamin K2 supplements.

Menaquinone-4 (MK-4) supplements

The other type of vitamin K2 supplement that persists on store shelves is menaquinone-4. MK-4 is a synthetic form of vitamin K2 that was one of the early vitamin K2 supplement forms. Although many scientific studies have used MK-4, it has several limitations, especially in terms of the required dose. The therapeutic dose of MK-4 used in most research is 45 mg (45,000 meg). This dose is permitted in the USA but far exceeds the Health Canada limit of 120 meg per dose. Imagine if someone owed you $45,000 but only paid you $120? MK-4 products are simply ineffective at such a low dose.

Proponents of MK-4 point out that it is the type of vitamin K2 that occurs naturally in animal-derived foods such as egg yolks and butter. While that is true, the MK-4 found in supplements is not extracted from these natural sources, it is synthesized in a laboratory. MK-7, on the other hand, is extracted from food and identical to what is found in natto. Just as natural vitamin D3 has gradually replaced synthetic vitamin D2 in most supplements, natural MK-7 will soon replace synthetic MK-4 on store shelves.

If the supplement you are considering just lists "vitamin K" and doesn't indicate whether it contains vitamin Kx or vitamin K2, MK-4 or MK-7, don't buy it. There's no way to tell what you are buying and whether it will deliver all the benefits of vitamin K2. Additionally, there's no need to spend money on supplements that contain vitamin K: since this nutrient easily obtained from the diet, the body recycles it, and deficiencies are extremely rare.


DOSAGE, SAFETY, AND DRUG INTERACTIONS

Vitamin K2 is very safe for adults and children, with no known toxic effects, unlike some other fat-soluble vitamins. A popular misconception is that high vitamin K{ or vitamin K2 intake will promote blood clots. Vitamin K supplements have no clotting effect, since coagulation proteins are already fully activated by vitamin Kj in people who are not on blood-thinning medications.

On the topic of medications, vitamin K2 supplements have no drug interactions, except in the case of warfarin (Coumadin). Because this type of blood thinner works by limiting the body's vitamin K metabolism, vitamin K supplements may interfere with the drug's efficacy. That being said, studies show that up to 50 meg of vitamin K2

(MK-7) can safely be taken with warfarin and may help the medication work more predictably and with fewer side effects. If you are taking a warfarin-type blood thinner, speak to a health care practitioner prior to supplementing with vitamin K2.

Other so-called "blood-thinning" medications such as aspirin, anti-platelet aggregators (e.g., Plavix), non-warfarin-type blood thinners (e.g.,Pradaxa), cardiac medications, and other drugs do not interact with vitamin K2.

As mentioned previously, current research shows the optimal daily dose of vitamin K2 (MK-7) is around 200 meg. Since most MK-7 supplements contain 100-120 meg per capsule or softgel, two per day will meet most needs. It's worth noting that frequent natto eaters safely get a lot more than 200 meg of MK-7 in their diet. Since this is a fat-soluble vitamin it's best taken with food for maximum absorption.
…………………………

AS  A  TEENAGE  I  TOOK  THE  “HEALTH  AND  STRENGTH  COURSE”  BY  CHARLES  ATLAS  [STILL  AVAILABLE - TYPE  IN  YOUR  INTERNET  BROWSER  CHARLES  ATLAS,  UP  IT  WILL  COME].  JUST  A  SUPER  FITNESS  COURSE.  CHARLES  WAS  VERY  STRICT  ON DIET.  AS  HE  SAID,  “YOU  ARE  WHAT  YOU  EAT.”
I  LEARNED  TO  LIKE  GOOD  WHOLE  RAW  MILK [YOU  COULD  GET  IT  BACK  IN  THE  1950s];  I  LOVED  REAL  BUTTER;  I  LOVED  EGGS;  I  LOVED  CHEESE;  I  LOVED  BAKED  BEANS;  YOU  COULD  SAY  I  GREW  UP  ON  THEM.  I  LOVED  ALSO  DIFFERENT  NUTS;  I  LOVED  DIFFERENT  VEGETABLES;  I  LOVED  VARIOUS  WHOLE  WHEAT   BREADS;  ONLY  A  FEW  CEREALS  I  LIKED— WHEATERBIX  AND  SHREDDED  WHEAT,  BOTH  WITH  HONEY.   I  LOVED  RAISINS,  DATES,  FIGS;  AND  I  LOVED  ALL  FRUITS.

ON  SUNDAYS  MOM  WOULD  COOK  A  BEEF  ROAST,  SLOWLY  OVER  MANY  HOURS,  VEGIES,  YORKSHIRE PUDDING,  ROAST  POTATOES,  GRAVY—— YUMMMMM…… FOR  DESERT  IT  WAS  OFTEN  HOME  MADE  ENGLISH  TRIFLE.

I  WAS  ON  A  GOOD  HEALTHY  BALANCED  DIET.  I  WAS  GETTING  VITAMIN  K2  THOUGH  I  DID  NOT  KNOW  IT.

MY  BONES  ARE  STILL  MIGHTY  STRONG [REGULAR  EXERCISING  HELPS  WITH  STRONG  BONES] —- FALLEN  OFF  ENOUGH  HORSES  IN  MY  LIFETIME  AND  NEVER  BROKEN  A  BONE.

I  DO  NOT  EAT  THREE  MEALS  A  DAY  ANY  MORE,  TO  KEEP  MY  WEIGHT  UNDER  CONTROL— METABOLISM  CHANGES  OVER  THE  DECADES;  SO  I  DO  TAKE  QUITE  A  FEW  VITAMIN  AND  MINERAL  SUPPLEMENTS.

MY  FACIAL  SKIN  IS  NOT  WRINKLED,  NO  BAGS  UNDER  THE  EYES,  NO  “GOOSE  NECK”—— IN  FACT  I  LOOK  YOUNGER  IN  PERSON  THAN  I  DO  ON  CAMERA.  YES  I’VE  USED  CREAM  ON  MY  FACE  AFTER  THE  MORNING  WASH,  FROM  A  TEENAGER,  WHICH  ALL  HELPED  THE  SKIN  ON  THE  OUTSIDE,  WHILE  A  GOOD  DIET  HELPED  ON  THE  INSIDE.

AND  NOW  THAT  THE  WORLD  OZONE  HAS  MENDED  ITSELF,  [TO  TAKE  OUT  THE  HARMFUL  RAYS  FROM  THE  SUN] I  HAVE  A  GREAT  SUN-TAN,  AS  CHARLES  ATLAS  SAID  YOU  SHOULD  GET.

IT  WOULD  SEEM  THE  WESTERN  WORLD  DOES  NOT  GET  ENOUGH  OF  VITAMIN  K2  AND  MAGNESIUM [VERY  VERY  IMPORTANT  FOR  DOZENS  OF  REASONS  IN  OUR  BODY];  AND  CANADIANS  DON’T  GET  ENOUGH  D3.

SO  SUPPLEMENTS  ARE  ONE  EASY  WAY  TO  FIX  THOSE   PROBLEMS.

I  DO  TAKE  ALL  THREE  SUPPLEMENTS.

Keith Hunt

Wednesday, May 16, 2018

MARIJUANA OR CANNABIS.....GETTING LEGALIZED MORE AND MORE...HERE'S WHY

Can Cannabis Fight Tumors?

can cannabis fight tumors

Story at-a-glance 

  • Cannabinoids interact with your body by way of naturally occurring cannabinoid receptors embedded in cell membranes throughout your body. It has a long history of use for pain and seizure disorders
  • Doctors working with medical cannabis are also using it to treat cancer-related side effects, and evidence suggests the herb may even have antitumor effects all on its own
  • Cannabis is proapoptotic, meaning it triggers cellular suicide of cancer cells while leaving healthy cells untouched, and antiangiogenic, meaning it cuts off a tumor's blood supply
  • CBD and THC together appears more effective against cancer than either of them in isolation. The sequence of administration also matters; when administered after chemotherapy, it induced greater apoptosis (cell death) than when administered prior to chemo
  • Another recent study suggests CBD from hemp may be helpful against ovarian cancer, reducing metastasis and slowing ovarian cancer better than the current ovarian cancer drug Cisplatin
By Dr. Mercola
Medical cannabis has a long history as a natural analgesic,1 and is now legal in 30 U.S. states,2,3 the majority of which allow limited use of medical marijuana under certain medical circumstances. The medicinal qualities of marijuana are primarily due to high amounts (about 10 to 20 percent) of cannabidiol (CBD), medicinal terpenes and flavonoids. 
Tetrahydrocannabinol (THC) is the psychoactive component of marijuana that makes you feel "stoned," but it too has valuable medical benefits, so depending on your problem, you may want higher or lower levels of THC. Cannabinoids interact with your body by way of naturally occurring cannabinoid receptors embedded in cell membranes throughout your body. 
There are cannabinoid receptors in your brain, lungs, liver, kidneys, immune system and more. Both the therapeutic and psychoactive properties of marijuana occur when a cannabinoid activates these cannabinoid receptors. 

Cannabis Has Long History of Use for Pain, Seizures and More

The U.S. government, through the Department of Health and Human Services (HHS), actually holds a patent on CBD as an antioxidant and neuroprotectant — an ironic and paradoxical situation considering the U.S. Drug Enforcement Administration has classified cannabis as a Schedule 1 controlled substance, which by definition has no accepted medical use.
This federal classification also makes it very difficult, time consuming and expensive to study the health effects of marijuana. Labs have to jump through a lot of legal hoops before being granted permission to study Schedule 1 drugs. Despite such difficulties, a number of studies have found a wide range of uses for the herb. For example, The Journal of Pain,4 a publication by the American Pain Society, has a long list of studies on the pain-relieving effects of cannabis. 
Cannabis also has been used for over 80 years for drug-resistant seizure disorders. In January 2015, the American Academy of Pediatrics updated its policy statement on marijuana,5 acknowledging that cannabinoids "may currently be an option for … children with life-limiting or severely debilitating conditions and for whom current therapies are inadequate." 
According to the National Institute on Drug Abuse,6 which also has information relating to the medicinal aspects of marijuana, preclinical and clinical trials are also underway to test marijuana and various extracts for the treatment of a number of diseases, including autoimmune diseases such as multiple sclerosis and Alzheimer's disease, inflammation, substance use disorders and mental disorders. 
CBD oil has also been shown7 to protect the brain of stroke patients and those with Parkinson's. It may also slow neurodegeneration caused by alcohol abuse. 

Cannabis Shows Promise as Anticancer Agent

Doctors working with medical cannabis are also using it to treat cancer-related side effects, and evidence suggests the herb may even have antitumor effects all on its own, with dozens of studies pointing to marijuana's effectiveness against many different types of cancer, including brain cancer, breast, prostate, lung, thyroid, colon and pituitary cancer, melanoma and leukemia.
It fights cancer via at least two mechanisms that make it difficult for a cancer to grow and spread: It's proapoptotic (meaning it triggers apoptosis or cellular suicide of cancer cells while leaving healthy cells untouched) and antiangiogenic (meaning it cuts off a tumor's blood supply). As recently reported by Scientific American:8
"… while the available data are limited, research that has been conducted around antitumor effects of cannabinoids so far shows great promise. The International Journal of Oncology published a study9 last year, for example, indicating that cannabinoids successfully kill cancer cells, and the benefits increase when combined with chemotherapy. 
An early preclinical study10 we recently conducted also found that cancer cells derived from patient blood samples were differentially sensitive to the two main active compounds in cannabis — tetrahydrocannabinol (THC) and tetrahydrocannabinolic acid (THCA). 
A number of other laboratory and animal studies have been conducted in recent years on colon, breast and brain cancers.11They indicate that cannabinoids may inhibit tumor growth by blocking cell growth, causing cell death and blocking the development of blood vessels that tumors require to grow."

CBD and THC Combo Improve Anticancer Drug Effectiveness

According to the International Journal of Oncology study mentioned, phytocannabinoids " possess anticancer activity when used alone, and a number have also been shown to combine favorably with each other in vitro in leukemia cells to generate improved activity." The best results were obtained when the cannabinoids were paired with the leukemia drugs cytarabine and vincristine. 
"Results show a number of cannabinoids could be paired together to generate an effect superior to that achieved if the components were used individually," the researchers write, noting that CBD and THC together appeared to be more effective than either of them in isolation. 
They also found that the sequence of administration mattered a great deal. When cannabinoids were administered after chemotherapy, it induced greater apoptosis or programmed cell death. When administered before, the opposite effect was achieved. According to the authors:
"Our results suggest that when certain cannabinoids are paired together, the resulting product can be combined synergistically with common anti-leukemia drugs allowing the dose of the cytotoxic agents to be dramatically reduced yet still remain efficacious. Nevertheless, the sequence of drug administration is crucial to the success of these triple combinations and should be considered when planning such treatments."

Hemp CBD Shows Promise Against Ovarian Cancer

Another recent study suggests CBD from hemp may be helpful against ovarian cancer. Hemp and marijuana plants are in the same family but differ in their THC content. While marijuana plants contain varying amounts of THC, hemp contains very little or none of this psychoactive ingredient. According to a report in Medical News Today,12 Sullivan University College of Pharmacy in Louisville, Kentucky, is "a hotbed of research into hemp's potential ability to fight cancer." 
Two of its laboratory researchers recently presented findings from two of its studies at the American Society for Biochemistry and Molecular Biology conference in San Diego. In the first,13 a strain called Kentucky hemp was found to reduce the ability of ovarian cancer cells to migrate, suggesting it could eventually be used to help prevent ovarian cancer metastasis. 
The second study14 found Kentucky hemp reduced secretion of interleukin IL-1 beta in ovarian cancer cells, thereby lowering inflammation associated with cancer progression. What's more, the researchers found Kentucky hemp "slows ovarian cancer comparable to, or even better than, the current ovarian cancer drug Cisplatin." The team is now planning additional studies using mice, with the hope of eventually graduating into human trials. 

Cannabis Versus Opioids

As mentioned, cannabis has well-proven analgesic properties, and evidence suggests it can be very helpful for those struggling with opioid addiction as well, easing withdrawal symptoms. In one recent study,15,16,17 138 seniors (ages 61 to 70) with osteoarthritis, stenosis or chronic hip or knee pain were prescribed medical marijuana to assess the effectiveness of the herb against pain, and whether it would have any impact on opioid use. 
Eighteen percent of the patients moderately decreased their use of other pain killers; 20 percent significantly reduced opioid use and 27 percent stopped using opioids altogether. In all, 91 percent said they would recommend cannabis to others. Forty-five percent of the patients in this study used vaporized oil, 28 percent used pills and 17 percent used marijuana-laced oil topically. Twenty-one percent used cannabis once a day, 23 percent twice a day, and 39 percent used it more than twice daily. 
The results were presented at the May 3 annual meeting of the American Geriatrics Society in Orlando, Florida. In an anonymous statement, one of the participants wrote, "My quality of life has increased considerably since starting medical marijuana. I was on opiates for 15 years, and six months on marijuana, [I'm] off both completely." 
Coauthor Dr. Diana Martins-Welch, a physician in the Division of Geriatric and Palliative Medicine, Department of Medicine at Northwell Health, also noted she's been able to get patients off opioids using medical marijuana.

Cannabis Legalization Has Led to Significant Decrease in Opioid Overdose Deaths

Another major benefit of cannabis is the fact that there's no risk of overdose or death. In fact, research from the Rand Corporation shows a 20 percent decline in opioid overdose deaths in states that had legalized medical marijuana, suggesting legalizing medical marijuana nationwide could save up to 10,000 lives a year. Together, these benefits make it a lead contender in the fight against rampant opioid abuse and escalating overdose deaths.18
CNN chief medical correspondent Dr. Sanjay Gupta recently published an open letter to U.S. attorney general Jeff Sessions, urging Sessions to change his stance on cannabis to help rein in the opioid epidemic. "Not only can cannabis work for a variety of conditions such as epilepsy, multiple sclerosis and pain, sometimes, it is the only thing that works … It is time for safe and regulated medical marijuana to be made available nationally," Gupta writes, adding:
"[P]erhaps most important, the compounds found in cannabis can heal the diseased addict's brain, helping them break the cycle of addiction. There is no other known substance that can accomplish all this. If we had to … design a medicine to help lead us out of the opioid epidemic, it would likely look very much like cannabis." 

Cannabis Eases Depression, Anxiety and Stress

Other recent research19 shows cannabis can help ease symptoms of depression, anxiety and stress. Unfortunately, depression and high stress are not recognized as a qualifying condition for a medical cannabis card in most states that have legalized the herb for medical use. The reason for this is largely due to lack of scientific support, Carrie Cuttler, Ph.D., author of the study, says. 
To evaluate the effectiveness of cannabis for mental health, the team analyzed data from Strainprint, a mobile application cannabis users can use to track changes in symptoms after using different doses and cannabis chemotypes. Overall, self-reported symptoms of depression decreased by 50 percent and perceived stress decreased by 58 percent with use of medical marijuana. 
Of those who inhaled cannabis, over 89 percent reported a reduction in depression; nearly 94 percent reported lower anxiety and over 93 percent reported fewer stress symptoms. 
The greatest stress reduction was achieved after 10 puffs or more, while just two puffs reduced symptoms of depression and anxiety. These are rather impressive results, but the authors do note that results "may be inflated in the present sample because those who regularly have symptom exacerbation following cannabis use may be less likely to continue to use it to treat their symptoms and track symptom changes over time."
Other studies have also shown cannabis can be very helpful for those struggling with post-traumatic distress disorder.20,21 Marijuana suppresses dream recall, so for those having nightmares, it can be transformative. Marijuana is also reported to help individuals stay focused in the present, which is beneficial for those experiencing flashbacks. 

THC Appears Particularly Beneficial Against Dementia 

Interestingly, animal research22 has shown THC — the psychoactive component of marijuana — has a particularly beneficial influence on the aging brain.23,24 Rather than dulling or impairing cognition in the elderly, THC appears to reverse the aging process and improve mental processes, raising the possibility it might be useful for the treatment of dementia.
To test the hypothesis, mice were given a small daily dose of THC over the course of one month at the age of 2 months, 12 months and again at 18 months of age. It is important to understand that mice typically live to be about 2 years old. The dose was small enough to avoid any psychoactive effects. 
Tests assessed the animals' learning, memory, orientation and recognition skills. Curiously, the 18-month-old mice given THC demonstrated cognitive skills equal to 2-month-old controls, while the placebo group suffered cognitive deterioration associated with normal aging.
According to one of the authors, neurobiology professor Andreas Zimmer, University of Bonn, "The treatment completely reversed the loss of performance in the old animals. We repeated these experiments many times. It's a very robust and profound effect." Even more remarkable, gene activity and the molecular profile in the brain tissue was that of much younger animals. 
Specifically, neurons in the hippocampus grew more synaptic spines — points of contact necessary for communication between neurons. According to Zimmer, the THC appeared to have "turned back the molecular clock" in the THC-treated animals. (Previous research has also shown that the brain ages much faster in mice who do not have functional receptors for THC, suggesting THC may be involved in the regulation of the aging process.25) The team is planning tests to see if the same holds true in human subjects. 
In an earlier study, researchers at the University of South Florida and Thomas Jefferson University found that low-dose THC also directly impedes the buildup of beta amyloid plaque in the brain,26,27 which is associated with the development of Alzheimer's, and enhances mitochondrial function in the brain. 
Medical marijuana is also known to reduce some of the non-memory-related symptoms typically experienced by Alzheimer's sufferers, including anxiety, irritability and rage,28 so cannabis may well have multiple benefits for those with dementia and Alzheimer's. 

Is Cannabis Right for You? 

While recreational use of marijuana is not advocated, it seems quite clear that certain strains grown specifically to boost medicinal qualities can have a significantly beneficial effect on a number of different ailments and diseases, including chronic pain. In 2010, the Center for Medical Cannabis Research released a report29 on 14 clinical studies about the use of marijuana for pain, most of which were FDA-approved, double-blind and placebo-controlled. 
This report revealed that marijuana not only controls pain well, but in many cases, it actually does so better than pharmaceutical alternatives. When cannabis is inhaled, smoked or vaporized, its effects are rapid and short-lasting. Orally, it's the most unpredictable and delayed. When ingesting it, it can take up to two hours to take effect, but if dosed appropriately, you can achieve once-a-day dosing with an edible medicine. 
Compared to opioids and many other drugs, cannabis is also far safer. Cannabidiol has no toxicity and it's virtually impossible to die from marijuana. It's also self-limiting, as excessive doses of THC will provoke anxiety, paranoia and nausea. Such side effects will disappear as the drug dissipates from your system without resulting in permanent harm, but it'll make you think twice about taking such a high dose again. Make the same mistake with an opioid, and chances are you'll end up in the morgue.
Just be sure to seek out a knowledgeable cannabis physician, as the proper dosing needs to be carefully ascertained. If you are seriously considering medical cannabis for pain, please see my interview with Dr. Alan Frankel, one of the leading medical cannabis physicians in the U.S. He can do consultations on the phone if you need specific questions answered. 
You can also learn more by reviewing my interviews with Dr. Margaret Gedde, who runs an alternative medical practice in Colorado where they specialize in the use of cannabis, and Todd Harrison, an attorney whose expertise is Food and Drug Law, in which he discusses the current legal status of CBD oil. 
Research relating to the use of cannabis can also be found on cancer.gov30,31 (the U.S. government's site on cancer). Simply enter "cannabis" into the search bar. You can also peruse the medical literature through PubMed,32 which is a public resource (again, simply enter "cannabis" or related terms into the search bar). 

Wednesday, May 9, 2018

USA OUT OF NUCLEAR DEAL WITH IRAN!

SO  PRESIDENT  TRUMP  SAYS  OFFICIALLY [MAY 8 - 2018] THE  USA  IS  OUT  OF  THE  IRAN  NUCLEAR  DEAL!

ONE  PROMISE  HE  IS  KEEPING;  BUT  OTHERS  ARE  NOT  SURE  IT’S  A  WISE  MOVE….TIME  WILL  TELL!


BUT  AS  I’VE  TOLD  YOU  BEFORE  AND  WILL  AGAIN—

THERE  WILL  NEVER  BE  A  WAR  BETWEEN  IRAN  AND  THE  USA.

ALSO  IRAN  WILL  NOT  START  THE  NEXT  AND  FINAL  WW3.

BIBLE  PROPHECY  TELLS  US  QUITE  PLAINLY  WHO  WILL  START  THE  NEXT  WORLD  WAR,  AND  IT  IS  NOT  IRAN.

YOU  CAN  SLEEP  AT  NIGHT  KNOWING  NEITHER  IRAN  OR  NORTH  KOREA,  WILL   START  WORLD  WAR  THREE;  IN  FACT  THOSE  TWO  COUNTRIES  PLAY  NO  SIGNIFICANT  ROLE  AT  ALL  IN  END  TIME  PROPHECY.

THE  BOTTOM  LINE  IS  IT  DOES  NOT  MATTER  WHAT  THE  USA  DOES  DO  OR  DOES  NOT  DO— WE  NEED  NOT  FEAR  ANYTHING  FROM  IRAN  OR  NORTH  KOREA.

THE  NEXT  AND  LAST  WORLD  WAR  WILL  COME  FROM  A  PLACE  MOST  TODAY  WOULD  HARDLY  EVER  GUESS  IF  THEY  WERE  ASKED.

ALL  FULLY  EXPLAINED  TO  YOU  ON  MY  WEBSITE (www.keithhunt.com)  UNDER  “PROPHECY.”

……….