THE BRAIN
by David Eagleman
The Teen Years
Only a couple of decades ago it was thought that brain development was mostly complete by the end of childhood. But we now know that the process of building a human brain takes up to twenty-five years. The teen years are a period of such important neural reorganization and change that it dramatically affects who we seem to be. Hormones coursing around our bodies cause obvious physical changes as we take on the appearance of adults - but out of sight our brains are undergoing equally monumental changes. These changes profoundly color how we behave and react to the world around us.
One of these changes has to do with an emerging sense of self - and with it, self-consciousness.
[THE AUTHOR PROBABLY DOES NOT EVEN THINK OF IT, BUT THE HISTORICAL FACT IN JEWISH HISTORY, IS THAT AT THE TIME OF CHRIST. HENCE 2,000 YEARS AGO, IT WAS COMMON PRACTICE THAT MARRIAGES WERE VERY YOUNG LADIES, 14, 15, 16 MARRYING A LITTLE OLDER YOUNG MEN. TO BE 20 AND NOT MARRIED WAS A FAMILY DISGRACE. AT THE AGE OF 12 YOU WERE A YOUNG MAN OR WOMAN. REMEMBER JESUS SAYING TO HIS MOTHER AT THE PASSOVER WHEN HE WAS 12, “I MUST BE ABOUT MY FATHER’S BUSINESS.” THE UPBRINGING AND EDUCATION OF JEWISH CHILDREN BACK THEN MUST HAVE BEEN EXTRA-ORDINARY! SO THE HUMAN MIND IS FLEXIBLE INDEED, AND CAN MATURE MUCH EARLIER THAN MOST BRAIN SCIENTISTS EVER IMAGINE - Keith Hunt]
To get a sense of the teen brain at work, we ran a simple experiment. With the help of my graduate student Ricky Savjani, we asked volunteers to sit on a stool in a shop window display. We then pulled back the curtain to expose the volunteer looking out on the world - to be gawked at by passersby.
Volunteers sat in a shop window, to be stared at by passersby. Teenagers have greater social anxiety than adults, reflecting the details of brain development during the adolescent years.
Before sending them into this socially awkward situation, we rigged up each volunteer so wed be able to measure their emotional response. We hooked them up with a device to measure the galvanic skin response (GSR), a useful proxy for anxiety: the more your sweat glands open, the higher your skin conductance will be. (This is, by the way, the same technology used in a lie detector, or polygraph test.)
Both adults and teens participated in our experiment. In adults, we observed a stress response from being stared at by strangers, exactly as expected. But in teenagers, that same experience caused social emotions to go into overdrive: the teens were much more anxious - some to the point of trembling - while they were being watched.
[WELL AGAIN DEPENDING ON THE FAMILY AND SOCIETY, EDUCATION ETC. ALL THIS DOES NOT HAVE TO BE - Keith Hunt]
Why the difference between the adults and teens? The answer involves an area of the brain called the medial prefrontal cortex (mPFC). This region becomes active when you think about your self - and especially the emotional significance of a situation to your self. Dr. Leah Somerville and her colleagues at Harvard University found that as one grows from childhood to adolescence, the mPFC becomes more active in social situations, peaking at around fifteen
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SCULPTING OF THE ADOLESCENT BRAIN
After childhood, just before the onset of puberty, there is a second period of overproduction: the prefrontal cortex sprouts new cells and new connections (synapses), thereby creating new pathways for molding. This excess is followed by approximately a decade of pruning: all through our teenage years, weaker connections are trimmed back while stronger connections are reinforced. As a result of this thinning out, the volume of the prefrontal cortex reduces by about I % per year during the teenage years. The shaping of circuits during the teen years sets us up for the lessons we learn on our paths to becoming adults.
Because these massive changes take place in brain areas required for higher reasoning and the control of urges, adolescence is a time of steep cognitive change. The dorsolateral prefrontal cortex, important for controlling impulses, is among the most belated regions to mature, not reaching its adult state until the early twenties. Well before neuroscientists worked out the details, car insurance companies noticed the consequences of incomplete brain maturation - and they accordingly charge more for teen drivers. Likewise, the criminal justice system has long held this intuition, and thus juveniles are treated differently than adults.
[THIS APPLIES FOR OUR SOCIETY OF THE WESTERN WORLD; BUT AS STATED JEWISH UPBRINGING OF CHILDREN 2,000 YEARS AGO WAS WAY WAY MORE ADVANCED AND MATURE, HENCE YOU WERE CONSIDERED A YOUNG ADULT AT AGE 12. THE BRAIN CAN BE MOLDED WAY MORE AT A YOUNGER AGE IF YOUR SOCIETY GUIDES BY MATURITY AND THE WORD OF GOD. I WAS INTRODUCED TO THE BIBLE AT AGE 7 IN A CHURCH OF ENGLAND SCHOOL, FIRST HAVE HOUR OF THE DAY WAS BIBLE. I ALSO ATTENDED SUNDAY SCHOOL IN LOCAL AREA. I WAS WAY MORE MATURE AT A 12, WAY MORE THAN AVERAGE 12 YEAR OLDS - Keith Hunt]
……
years old. At this point, social situations carry a lot of emotional weight, resulting in a self-conscious stress response of high intensity. That is, in adolescence, thinking about ones self - so-called "self evaluation" - is a high priority. In contrast, an adult brain has grown accustomed to a sense of self - like having broken in a new pair of shoes - and as a result an adult doesn't care as much about sitting in the shop window.
[AGAIN FOR OUR WESTERN SOCIETY TODAY THIS IS SO, BUT DOES NOT HAVE TO BE - Keith Hunt]
Beyond social awkwardness and emotional hypersensitivity, the teen brain is set up to take risks. Whether its driving fast or sexting naked photos, risky behaviors are more tempting to the teen brain than to the adult brain. Much of that has to do with the way we respond to rewards and incentives. As we move from childhood into adolescence, the brain shows an increasing response to rewards in areas related to pleasure seeking (one such area is called the nucleus accumbens). In teens, the activity here is as high as it is in adults. But here's the important fact: activity in the orbitofrontal cortex - involved in executive decision making, attention, and simulating future consequences - is still about the same in teens as it is in children. A mature pleasure-seeking system coupled with an immature orbitofrontal cortex means that teens are not only emotionally hypersensitive, but also less able to control their emotions than adults.
[AGAIN IT IS SO IN OUR WESTERN SOCIETIES, DOES NOT MEAN IT IS SO FOR OTHER SOCIETIES, LIKE THE JEWISH SOCIETY AT JESUS’ TIME; THE RIGHT EDUCATION BASED ON GOD’S WORD CAN MAKE A HUGE DIFFERENCE - Keith Hunt]
Moreover, Somerville and her team have an idea why peer pressure strongly compels behavior in teens: areas involved in social considerations (such as the mPFC) are more strongly coupled to other brain regions that translate motivations into actions (the striatum and its network of connections). This, they suggest, might explain why teens are more likely to take risks when their friends are around.
Due to changes in many brain areas involved in reward, planning, and motivation, our sense of self undergoes major changes in our teenage years.
[ALL OF THIS IS BASED UPON OUR GODLESS WESTERN SOCIETIES, HENCE WAY MORE IMMATURE FOR WAY MORE YEARS, THAN A SOCIETY FOUNDED ON GOD’S WORD AND WAY OF LIVING - Keith Hunt]
How we see the world as a teenager is the consequence of a changing brain that's right on schedule. These changes lead us to be more self-conscious, more risk-taking, and more prone to peer-motivated behavior. For frustrated parents the world over, there's an important message: who we are as a teenager is not simply the result of a choice or an attitude; it is the product of a period of intense and inevitable neural change.
[JUST NOT SO. NONE OF WHAT THE AUTHOR SAYS WAS ME, DURING MY TEENS, FAR FROM IT, BECAUSE I WAS RAISED ON THE WORD OF GOD AND TOOK HIS WORD VERY SERIOUSLY. I WAS NOT YOUR “TYPICAL” TEENAGER, NOT AT ALL. SOCIETY HAS ALSO CHANGED SINCE THROWING THE BIBLE AND GOD OUT THE WINDOW, AND TEENS TODAY FOR THE MOST PART ARE NOT ANYWHERE NEAR THE MATURITY OF TEENS IN MY TIME, BACK IN THE 1950S - Keith Hunt]
Plasticity in Adulthood
By the time we're twenty-five years of age, the brain transformations of childhood and adolescence are finally over. The tectonic shifts in our identity and personality have ended, and our brain appears to now be fully developed. You might think that who we are as adults is now fixed in place, immoveable. But it's not: in adulthood our brains continue to change. Something that can be shaped - and can hold that shape - is what we describe as plastic. And so it is with the brain, even in adulthood: experience changes it, and it retains the change.
[AND SO IT IS IN TEENAGE ALSO….. CAN CHANGE, BE SHAPED, MOLDED, IF THE RIGHT EDUCATION AND WORD OF GOD IS PART OF A TEENS LIFE…. THEY CAN MENTALLY MATURE MUCH FASTER - Keith Hunt]
To get a sense of how impressive these physical changes can be, consider the brains of a particular group of men and women who work in London: the city's cab drivers. They undergo four years of intensive training to pass the "Knowledge of London", one of society's most difficult feats of memory. The Knowledge requires aspiring cabbies to memorize London's extensive roadways, in all their combinations and permutations. This is an exceedingly difficult task: The Knowledge covers 320 different routes through the city, 25,000 individual streets, and 20,000 landmarks and points of interest - hotels, theatres, restaurants, embassies, police stations, sports facilities, and anywhere a passenger is likely to want to go. Students of The Knowledge typically spend three to four hours a day reciting theoretical journeys.
……
In an epic feat of memorization, London cab drivers learn the city's geography by rote. After training, they can articulate the most direct (and legal!) route between any two points in the greater metropolitan area, without consulting a map,The end result of the challenge is a visible change in their brains.
……
The unique mental challenges of The Knowledge sparked the interest of a group of neuroscientists from University College London, who scanned the brains of several cab drivers. The scientists were particularly interested in a small area of the brain called the hippocampus - vital for memory, and, in particular, spatial memory.
The scientists discovered visible differences in the cabbies' brains: in the drivers, the posterior part of the hippocampus had grown physically larger than those in the control group - presumably causing their increased spatial memory. The researchers also found that the longer a cabbie has been doing his job, the bigger the change in that brain region, suggesting that the result was not simply reflecting a pre-existing condition of people who go into the profession, but instead resulted from practice.
The cab-driver study demonstrates that adult brains are not fixed in place, but instead can reconfigure so much that the change is visible to the trained eye.
[AND SO IT CAN BE IN CHILDREN AS THEY GROW. I HAD TO LEARN MANY PSLAMS BY MEMORY, AND THE 10 COMMANDMENTS AS IN EXODUS 20, THE LONG FORM. A YOUNG MIND, A TEENS MIND CAN BE LIKE A HUGE SPONGE, HENCE UNDER SUCH A LIVING SOCIETY MATURITY COME MUCH FASTER, WAY FASTER THAN OUR GODLESS SOCIETIES TODAY - Keith Hunt]
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After learning The Knowledge, the hippocampuses of London cab drivers visibly changed shape -reflecting their improved skills of spatial navigation
.……
Its not just cab drivers whose brains reshape themselves. When one of the most famous brains of the twentieth century was examined, Albert Einstein's brain did not reveal the secret of his genius. But it did show that the brain area devoted to his left fingers had expanded - forming a giant fold in his cortex called the Omega sign, shaped like the Greek symbol Q - all thanks to his less commonly known passion for playing the violin. This fold becomes enlarged in experienced violin players, who intensively develop fine dexterity with the fingers of their left hand. Piano players, in contrast, develop an Omega sign in both hemispheres, as they use both hands in fine, detailed movements.
Albert Einstein and his brain.The brain is viewed from above; the front of the brain is at the top of the picture.The orange shaded region is unusually enlarged - so much so that the extra tissue bunches up into what looks like an upside-down Greek letter omega.
The shape of the hills and valleys in the brain is largely conserved across people - but the finer details give a personal and unique reflection of where you've been and who you are now. Although most of the changes are too small to detect with the naked eye, everything you've experienced has altered the physical structure of your brain - from the expression of genes to the positions of molecules to the architecture of neurons. Your family of origin, your culture, your friends, your work, every movie you’ve watched, every conversation you’ve had - these have all left their footprints in your nervous system. These indelible, microscopic impressions accumulate to make you who you are, and to constrain who you can become.
[YES JUST WHAT I’VE BEEN SAYING; SO BRAIN MATURITY IS DEPENDANT ON MANY THINGS AS JUST MENTIONED BY THE AUTHOR; IT IS NOT ALL CUT AND DRY. TODAYS WESTERN SOCIETIES ARE NOT ANYTHING TO GO BY, MATURITY OF MIND IS NOT FOUNDED ON GOOD AND RIGHTEOUS WAYS OF LIVING, SO MATURITY FOR MOST TAKES MUCH LONGER, MUCH LONGER TODAY THAN IN JESUS’ JEWISH COMMUNITY - Keith Hunt]
Pathological Changes
Changes in our brain represent what we've done and who we are. But what happens if the brain changes because of a disease or injury? Does this also alter who we are, our personalities, our actions?
On August 1st 1966, Charles Whitman took an elevator to the observation deck of the University of Texas Tower in Austin. Then the twenty-five-year-old started firing indiscriminately at people below. Thirteen people were killed and thirty-three wounded, until Whitman himself was finally shot dead by police. When they got to his house they discovered that he had killed his wife and mother the night before.
There was only one thing more surprising than this random act of violence, and that was the lack of anything about Charles Whitman that would seem to have predicted it. He was an Eagle Scout, he was employed as a bank teller, and he was an engineering student.
Police photograph of the body of Charles Whitman after he went on a murderous shooting spree at the University of Texas at Austin in 1966, In his suicide note, Whitman asked for an autopsy: he suspected that something was going awry in his brain.
Shortly after killing his wife and his mother, he'd sat down and typed what amounted to a suicide note:
I don’t really understand myself these days. I am supposed to be an average reasonable and intelligent young man. However, lately (I cannot recall when it started) I have been a victim of many unusual and irrational thoughts . . . After my death I wish that an autopsy would be performed on me to see if there is any visible physical disorder.
Whitmans request was granted. After an autopsy, the pathologist reported that Whitman had a small brain tumor. It was about the size of a nickel, and it was pressing against a part of his brain called the amygdala, which is involved in fear and aggression. This small amount of pressure on the amygdala led to a cascade of consequences in Whitmans brain, resulting in him taking actions that would otherwise be completely out of character. His brain matter had been changing, and who he was changed with it.
This is an extreme example, but less dramatic changes in your brain can alter the fabric of who you are. Consider the ingestion of drugs or alcohol. Particular kinds of epilepsy make people more religious. Parkinsons disease often makes people lose their faith, while the medication for Parkinsons can often turn people into compulsive gamblers. Its not just illness or chemicals that change us: from the movies we watch to the jobs we work, everything contributes to a continual reshaping of the neural networks we summarize as us. So who exactly are you? Is there anyone down deep, at the core?
[YES THE “SPIRIT IN MAN” WHICH ALL NORMAL BABIES HAVE, DOES NOT TAKE OVER IF THE MIND OR BRAIN IS DAMAGED. A FALL MAY LEAVE YOU WITHOUT SIGHT, THE SPIRIT IN MAN DOES NOT TAKE OVER AND SEE FOR YOU AND ETC. WITH OTHER EXAMPLES. THE SPIRIT IN MAN GIVES YOU THE UNIQUE ABILITY TO THINK, REASON, JUDGE, INVENT, UNDERSTAND, AS ONLY HUMANS CAN, AND NO OTHER CREATURE HAS THIS KIND OF ABILITY. THEY ALSO HAVE BRAINS WHICH CAN FLEX TO SOME DEGREE, SOME ANIMALS MORE THAN OTHERS, AND SOME ANIMAL MORE THAN OTHERS IN THE SAME GROUP. BUT ONLY MANKIND HAS THE SPIRIT IN MAN THAT MAKES HIM UNIQUE - Keith Hunt]
Am I the Sum of my Memories?
Our brains and bodies change so much during our life that - like a clock’s hour hand - it’s difficult to detect the changes. Every four months your red blood cells are entirely replaced, for instance, and your skin cells are replaced every few weeks. Within about seven years every atom in your body will be replaced by other atoms. Physically, you are constantly a new you. Fortunately, there may be one constant that links all these different versions of your self together: memory. Perhaps memory can serve as the thread that makes you who you are. It sits at the core of your identity, providing a single, continuous sense of self.
[YES THAT IS INDEED SO. OUR UNQUE MEMORY AND OUR SPIRIT IN MAN, MAKES EACH ONE OF US HUMANS UNQUE FROM ALL OTHER HUMANS - Keith Hunt]
But there might be a problem here. Could the continuity be an illusion? Imagine you could walk into a park and meet your self at different ages in your life. There you are aged six; as a teenager; in your late twenties; mid-fifties; early seventies; all the way through your final years. In this scenario, you could all sit together and share the same stories about your life, teasing out the single thread of your identity.
Or could you? You all possess the name and history, but the fact is that you're all somewhat different people, in possession of different values and goals. And your life's memories might have less in common than expected. Your memory of who you were at fifteen is different to who you actually were at fifteen; moreover, you'll have different memories that relate back to the same events. Why? Because of what a memory is - and isn't.
Imagine a person could be split into herself at all her different ages. Would they all agree on the same memories? If not, are they really the same person?
Rather than memory being an accurate video recording of a moment in your life, it is a fragile brain state from a bygone time that must be resurrected for you to remember.
Here's an example: you're at a restaurant for a friend's birthday. Everything you experience triggers particular patterns of activity in your brain. For example, there's a particular pattern of activity sparked into life by the conversation between your friends. Another pattern is activated by the smell of the coffee; yet another by the taste of a delicious little French cake. The fact that the waiter puts his thumb in your cup is another memorable detail, represented by a different configuration of neurons firing. All of these constellations become linked with one another in a vast associative network of neurons that the hippocampus replays, over and over, until the associations become fixed. The neurons that are active at the same time will establish stronger connections between them: cells that fire together, wire together. The resulting network is the unique signature of the event, and it represents your memory of the birthday dinner.
Your memory of art event is represented by the unique constellation of cells involved in the details you experience.
Now lets imagine that six months later you taste one of those little French cakes, just like the one you tasted at the birthday party. This very specific key can unlock the whole web of associations. The original constellation lights up, like the lights of a city switching on. And suddenly you're back in that memory.
Although we don't always realize it, the memory is not as rich as you might have expected. You know that your friends were there. He must have been wearing a suit, because he always wears a suit. And she was wearing a blue shirt. Or maybe it was purple? It might have been green. If you really probe the memory, you'll realize that you can't remember the details of any of the other diners at the restaurant, even though the place was full.
So your memory of the birthday meal has started to fade. Why? For a start, you have a finite number of neurons, and they are all required to multitask. Each neuron participates in different constellations at different times. Your neurons operate in a dynamic matrix of shifting relationships, and heavy demand is continually placed on them to wire with others. So your memory of the birthday dinner has become muddied, as those "birthday" neurons have been co-opted to participate in other memory networks. The enemy of memory isn't time; it's other memories. Each new event needs to establish new relationships among a finite number of neurons. The surprise is that a faded memory doesn't seem faded to you. You feel, or at least assume, that the full picture is there.
And your memory of the event is even more dubious. Say that in the intervening year since the dinner, your two friends have split up. Thinking back on the dinner, you might now misremember sensing red flags. Wasn't he more quiet than usual that night? Weren't there moments of awkward silence between the two? Well, it will be difficult to know for certain, because the knowledge that's in your network now changes the memory that corresponds to then. You can't help but have your present color your past. So a single event may be perceived somewhat differently by you at different stages in your life.
[SOME MEMORIES FOR WHATEVER REASON STAY WITH YOU AS IF THEY HAPPENED YESTERDAY, OTHERS ARE FADING, SOME THINGS HAVE FADED AWAY COMPLETELY, THEY ARE GONE. GROWING UP MY MOM WOULD ASK ME AT TIMES, “DO YOU REMEMBER THE TIME A BOY CUT YOUR FACE WITH A SHARP STICK, YOU WERE ABBOUT 4 YEARS OLD?” I WOULD SAY, “NO MOM I DO NOT REMEMBER THAT AT ALL.” BUT I CAN REMEMBER OTHER THINGS AT AGE 3, 4, 5, LIKE IT HAPPENED YESTERDAY - Keith Hunt]
The Fallibility of Memory
Clues to the malleability of our memory come from the pioneering work of Professor Elizabeth Loftus at University of California, Irvine. She transformed the field of memory research by showing how susceptible memories are.
Loftus devised an experiment in which she invited volunteers to watch films of car crashes, and then asked them a series of questions to test what they remembered. The questions she asked influenced the answers she received. She explains: "When I asked how fast were the cars going when they hit each other, versus how fast were the cars going when they smashed into each other, witnesses give different estimates of speed. They thought the cars were going faster when I used the word smashed." Intrigued by the way that leading questions could contaminate memory, she decided to go further.
Would it be possible to implant entirely false memories? To find out, she recruited a selection of participants, and had her team contact their families to get information about events in their past. Armed with this information, the researchers put together four stories about each participants childhood. Three were true. The fourth story contained plausible information, but was entirely made up. The fourth story was about getting lost in a shopping mall as a child, being found by a kind elderly person, and finally being reunited with a parent.
In a series of interviews, participants were told the four stories. At least a quarter claimed they could remember the incident of being lost in the mall - even though it hadn't actually happened. And it didn't stop there. Loftus explains: "They may start to remember a little bit about it. But when they come back a week later, they're starting to remember more. Maybe they'll talk about the older woman, who rescued them." Over time, more and more detail crept into the false memory: "The old lady was wearing this crazy hat"; "I had my favorite toy with me"; "My mom was so mad".
So not only was it possible to implant false new memories in the brain, but people embraced and embellished them, unknowingly weaving fantasy into the fabric of their identity.
We're all susceptible to this memory manipulation - even Loftus herself. As it turns out, when Elizabeth was a child, her mother had drowned in a swimming pool. Years later, a conversation with a relative brought out an extraordinary fact: that Elizabeth had been the one to find her mothers body in the pool. That news came as a shock to her; she hadn't known that, and in fact she didn't believe it. But, she describes, "I went home from that birthday and I started to think: maybe I did. I started to think about other things that I did remember - like when the firemen came, they gave me oxygen. Maybe I needed the oxygen cause I was so upset that I found the body?" Soon, she could visualize her mother in the swimming pool.
But then her relative called to say he had made a mistake. It wasn't the young Elizabeth after all who had found the body. It had been Elizabeth's aunt. And that's how Loftus had the opportunity to experience what it was like to possess her own false memory, richly detailed and deeply felt.
Our past is not a faithful record. Instead it's a reconstruction, and sometimes it can border on mythology. When we review our life memories, we should do so with the awareness that not all the details are accurate. Some came from stories that people told us about ourselves; others were filled in with what we thought must have happened. So if your answer to who you are is based simply on your memories, that makes your identity something of a strange, ongoing, mutable narrative.
[AND SO IT SHOWS HOW SUSCEPTIBLE WE CAN BE TO FALSE IDEAS, AND EVEN THE INFLUENCE OF THE DEMONIC FORCES; WE HAVE TO GUARD OUR MIND ALL THE TIME. THANKFULLY I WAS BROUGHT UP ON THE BIBLE WHICH DEFINITELY HELP TO AVOID ABSORBING SOME THINGS LIKE WHICH ARE MENTIONED ABOVE - Keith Hunt]
The Aging Brain
Today we're living longer than at any point in human history - and this presents challenges for maintaining brain health. Diseases like Alzheimer's and Parkinson's attack our brain tissue, and with it, the essence of who we are.
But here's the good news: in the same way that your environment and behavior shape your brain when you're younger, they are just as important in your later years.
MEMORY OF THE FUTURE
Henry Molaison suffered his first major epileptic seizure on his fifteenth birthday. From there, the seizures grew more frequent. Faced with a future of violent convulsions, Henry underwent an experimental surgery - one which removed the middle part of the temporal lobe (including the hippocampus) on both sides of his brain. Henry was cured of the seizures, but with a dire side effect: for the rest of his life, he was unable to establish any new memories.
But the story doesn't end there. Beyond his inability to form new memories, he was also unable to imagine the future.
Picture what it would be like to go to the beach tomorrow. What do you conjure up? Surfers and sandcastles? Crashing waves? Rays of sun breaking through clouds? If you were to ask Henry what he might imagine, a typical response might be,"all I can come up with is the color blue". His misfortune reveals something about the brain mechanisms that underlie memory: their purpose is not simply to record what has gone before but to allow us to project forward into the future.To imagine tomorrow's experience at the beach, the hippocampus, in particular, plays a key role in assembling an imagined future by recombining information from our past.
Across the US, more than 1,100 nuns, priests, and brothers have been taking part in a unique research project - The Religious Orders Study - to explore the effects of aging on the brain. In particular the study is interested in teasing out the risk factors for Alzheimer's disease, and it includes subjects, aged sixty-five and over, who are symptom-free and don't exhibit any measurable signs of disease.
Keeping a busy lifestyle into old age benefits the brain.
In addition to being a stable group that can be easily tracked down each year for regular tests, the religious orders share a similar lifestyle, including nutrition and living standards. This allows for fewer so-called "confounding factors", or differences, that might arise in the wider population, like diet or socioeconomic status or education - all of which could interfere with the study results.
Data collection began in 1994. So far, Dr. David Bennett and his team at Rush University in Chicago have collected over 350 brains. Each one is carefully preserved, and examined for microscopic evidence of age-related brain diseases. And that's only half the study: the other half involves the collection of in-depth data on each participant while they're alive. Every year, everyone in the study undergoes a battery of tests, ranging from psychological and cognitive appraisals to medical, physical, and genetic tests.
Hundreds of nuns have donated their brains for examination after their death. Researchers were caught off guard by the results.
When the team began their research, they expected to find a clear-cut link between cognitive decline and the three diseases that are the most common causes of dementia: Alzheimer's, Stroke and Parkinson's. Instead, here's what they found: having brain tissue that was being riddled with the ravages of Alzheimer's disease didn't necessarily mean a person would experience cognitive problems. Some people were dying with a full-blown Alzheimer's pathology without having cognitive loss. What was going on?
The team went back to their substantial data sets for clues. Bennett found that psychological and experiential factors determined whether there was loss of cognition. Specifically, cognitive exercise - that is, activity that keeps the brain active, like crosswords, reading, driving, learning new skills, and having responsibilities - was protective. So were social activity, social networks and interactions, and physical activity.
On the flip side, they found that negative psychological factors like loneliness, anxiety, depression, and proneness to psychological distress were related to more rapid cognitive decline. Positive traits like conscientiousness, purpose in life, and keeping busy were protective.
The participants with diseased neural tissue - but no cognitive symptoms - have built up what is known as "cognitive reserve". As areas of brain tissue have degenerated, other areas have been well exercised, and therefore have compensated or taken over those functions. The more we keep our brains cognitively fit - typically by challenging them with difficult and novel tasks, including social interaction - the more the neural networks build new roadways to get from A to B.
Think of the brain like a toolbox. If its a good toolbox, it will contain all the tools you need to get a job done. If you need to disengage a bolt, you might fish out a ratchet; if you don't have access to the ratchet, you'll pull out a wrench; if the wrench is missing you might try a pair of pliers. Its the same concept in a cognitively fit brain: even if many pathways degenerate because of disease, the brain can retrieve other solutions.
The nuns' brains demonstrate that it's possible to protect our brains, and to help hold on to who we are for as long as possible. We can't stop the process of aging, but by practicing all the skills in our cognitive toolbox, we may be able to slow it down.
[OH YES INDEED, I’M A GREAT BELIEVER IN BEING ABLE TO SLOW DOWN AGING; RIGHT HEALTHY FOODS, PHYSICAL EXERCISE, CORRECT AMOUNT OF SLEEP, KEEPING THE BRAIN ACTIVE. THIS WAS THE WAY CHARLES ATLAS AND HIS “HEALTH AND STRENGTH” COURSE TAIGHT OVER AND OVER…… IT WORKS; I’VE PROVED AND AM STILL PROVING IT. IT IS ALSO WHAT IS TAUGHT IN THE BOOK “REAL AGE” BY DR. MICHAEL F. ROIZEN. I AM 75 BUT THAT IS MY BIRTH AGE, MY REAL AGE BIOLOGICALLY IS 55 - AND THE TRUTH BE TOLD I’M PROBABLY MENTALLY AND PHYSICALLY FITTER THAN MANY 55 YEAR OLD PEOPLE - Keith Hunt]
I Am Sentient
When I think about who I am, there's one aspect above all that can't be ignored: I am a sentient being. I experience my existence. I feel like I'm here, looking out on the world through these eyes, perceiving this Technicolor show from my own center stage. Let's call this feeling consciousness or awareness.
Scientists often debate the detailed definition of consciousness, but it's easy enough to pin down what we're talking about with the help of a simple comparison: when you're awake you have consciousness, and when you're in deep sleep you don't. That distinction gives us an inroad for a simple question: what is the difference in brain activity between those two states?
One way to measure that is with electroencephalography (EEG), which captures a summary of billions of neurons firing by picking up weak electrical signals on the outside of the skull. Its a bit of a crude technique; sometimes its compared to trying to understand the rules of baseball by holding a microphone against the outside of a baseball stadium. Nonetheless, EEG can offer immediate insights into the differences between the waking and sleeping states.
When you're awake, your brain waves reveal that your billions of neurons are engaged in complex exchanges with one another: think of it like thousands of individual conversations in the ballgame crowd.
When you go to sleep, your body seems to shut down. So it's a natural assumption that the neuronal stadium quiets down. But in 1953 it was discovered that such an assumption is incorrect: the brain is just as active at night as during the day. During sleep, neurons simply coordinate with one another differently, entering a more synchronized, rhythmic state. Imagine the crowd at the stadium doing an incessant Mexican wave, around and around.
Consciousness emerges when neurons are coordinating with one another in
complex, subtle, mostly independent rhythms. In slow-wave sleep, neurons are more
synchronized with one another, and consciousness is absent.
As you can imagine, the complexity of the discussion in a stadium is much richer when thousands of discrete conversations are playing out. In contrast, when the crowd is entrained in a bellowing wave, it's a less intellectual time.
So who you are at any given moment depends on the detailed rhythms of your neuronal firing. During the day, the conscious you emerges from that integrated neural complexity. At night, when the interaction of your neurons changes just a bit, you disappear. Your loved ones have to wait until the next morning, when your neurons let the wave die and work themselves back into their complex rhythm. Only then do you return. So who you are depends on what your neurons are up to, moment by moment.
THE MIND-BODY PROBLEM
Conscious awareness is one of the most baffling puzzles of modern neuroscience. What is the relationship between our mental experience and our physical brains?
The philosopher Rene Descartes assumed that an immaterial soul exists separately from the brain. His speculation, depicted in the figure, was that sensory input feeds into the pineal gland, which serves as the gateway to the immaterial spirit. (He most likely chose the pineal gland simply because it sits on the brain's midline, while most other brain features are doubled, one on each hemisphere.)
The idea of an immaterial soul is easy to imagine; however, it's difficult to reconcile with neuroscientific evidence. Descartes never got to wander a neurology ward. If he had, he would have seen that when brains change, people's personalities change. Some kinds of brain damage make people depressed. Other changes make them manic. Others adjust a person's religiosity, sense of humor, or appetite for gambling. Others make a person indecisive, delusional, or aggressive. Hence the difficulty in the framework that the mental is separable from the physical.
As we'll see, modern neuroscience works to tease out the relationship of detailed neural activity to specific states of consciousness. It's likely that a full understanding of consciousness will require new discoveries and theories; our field is still quite young.
[AH AH, ONE MAN THAT WAS RIGHT ON THE BUTTON; HE WAS CORRECT THAT THERE IS AN IMMORTAL SPIRIT IN MAN, THAT GOES BACK TO GOD WHO GAVE IT - ECCL. 12: 9.
IT IS THE BUILT IN CD THAT RECORDS YOU AS A HEALTHY RIGHTEOUS PERSON, IF IN GOD AND JESUS AS PERSONAL SAVIOR, YOU ARE UNDER GRACE - ONLY RIGHTEOUS IS RECORDED; ALL SINS ARE WASHED AWAY IN THE SACRIFICIAL BLOOD OF THE LAMB JESUS - Keith Hunt]
Brains Are Like Snowflakes
After I finished graduate school, I had the opportunity to work with one of my scientific heroes, Francis Crick. By the time I met him, he had turned his efforts to addressing the problem of consciousness. The chalkboard in his office contained a great deal of writing; what always struck me was that one word was written in the middle much larger than the rest. That word was "meaning". We know a lot about the mechanics of neurons and networks and brain regions - but we don't know why all those signals coursing around in there mean anything to us. How can the matter of our brains cause us to care about anything?
The meaning problem is not yet solved. But here's what I think we can say: the meaning of something to you is all about your webs of associations, based on the whole history of your life experiences.
Imagine I were to take a piece of cloth, put some colored pigments on it, and display it to your visual system. Is that likely to trigger memories and fire up your imagination? Well, probably not, because it's just a piece of cloth, right?
But now imagine that those pigments on a cloth are arranged into a pattern of a national flag. Almost certainly that sight will trigger something for you - but the specific meaning is unique to your history of experiences. You don't perceive objects as they are. You perceive them as you are.
Each of us is on our own trajectory - steered by our genes and our experiences - and as a result every brain has a different internal life. Brains are as unique as snowflakes.
As your trillions of new connections continually form and re-form, the distinctive pattern means that no one like you has ever existed, or will ever exist again. The experience of your conscious awareness, right now, is unique to you.
And because the physical stuff is constantly changing, we are too. We’re not fixed. From cradle to grave, we are works in progress.
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YES WE ARE INDEED WORKS IN PROGRESS…..THE BODY, BRAIN. SHOULD NEVER RETIRE, KEEPING YOUR BODY AND MIND IN ACTIVITY ARE HEALTH KEYS THAT KEEP US YOUNG, TOGETHER WITH A BALANCED APPROACH ON WHAT YOU EAT, AND THE CORRECT NUMBER OF HOURS WE SLEEP - Keith Hunt
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